When an Inhuman ship carrying Seeker and the Alpha Primitives crashes into the mountains near Maple Falls, the Avengers respond to a distress call where they have a brief fight with Black Bolt, Medusa, Gorgon, and Karnak until a Terrigen cocoon in a nearby building hatches Inferno. The Avengers and the Inhumans had to work together to fight Inferno. After Hulk and Lockjaw obtain the crystal need for a device that will disperse the Terrigen Cloud, the Alpha Primitives and Inferno start acting like themselves again. What the Avengers and the Inhumans don't know yet is that Seeker had staged this incident in collaboration with Ultron. In the episode "The Inhuman Condition", Ultron has invaded Attilan and captures every Inhuman except for Black Bolt, Lockjaw, and Seeker. The Avengers come to their aid where it was discovered that Seeker invented a device that would dispense the Terrigen Mist on Earth that would transform other Inhuman descendants like Inferno. After Ultron reworked the device to phase-shift Seeker, he began to use a larger version of it in order to eliminate mankind. Thanks to Black Widow throwing a Terrigen Crystal in it following the Inhumans being rescued, Ultron's plans are thwarted as the Terrigen Mists transform those who are Inhuman descendants into Inhumans. In the four part "Civil War" episodes, Truman Marsh moves ahead with the Inhumans Registration Act where the Inhumans will have Registration Disks placed on them. The Registration Disks were part of a plot by Ultron to control them into furthering his goals. The Avengers were able to free the Inhumans from the Registration Disks.