The Super Soldier Serum is a special formula created by Abraham Erskine in WW2 which gives the user enhanced superhuman abilities. The formula has a permanent affect on the human biology, & it is possibly a virus, because serums have a temporary affect on any human being. It also amplifies their key personality traits.

Variants & Properties

20th Century Variants

The original strain of the super-soldier serum is known to give enhance physical attributes based on the subject's key personality traits. Once injected into a subject's bloodstream, it "heals" the subject to full health & gives the subject extraordinary muscular power, a muscular physique, an advanced resilience to fatigue, pain, infections, intoxication & physical & mental trauma. It also enhances the host's reaction, thinking & movement speed as well as grants the host an increase in intelligence & a far more efficient metabolism. Lastly, the subject gains the ability to heal at an accelerated rate & slows the aging process to border immortality, however regeneration of amputated limbs is unlikely. The variant also gives special powers based on the host's personality. An example would be how the Herr Johann Schmidt's mutated appearance is a reflection of his desire to be removed from the human race as well as his evil nature, thus turning him into the Red Skull. Another example would be how Steve Rogers desire to be a protector of freedom & the weak, made him physically & mentally evolve beyond the maximum human limits, thus turning him into Captain America. Bucky Barnes' subconscious will to protect Steve Rogers at all costs gave him the durability & healing ability to survive a fall down the Swiss Alps, even though he lost his left arm. However, due to the brainwashing done by HYDRA, he became the Winter Soldier.

A variant of the super-soldier serum was designed Heinrich Zemo, showing near-identical enhancements to Erskine's formula, having allowed Baron Zemo to gain enhanced strength, agility, stamina, intelligence & healing factor which is on par or slightly beyond Captain America's capabilities. This serum may also provide powers based on key personality traits, as Baron Helmut Zemo's desires to become youthful was granted as he de-aged to a man in his 30's within a several moments.

21st Century Variants

A new super-soldier serum developed by top-level S.H.I.E.L.D. scientists, Walter & Amanda Cage, causes unusually different reactions in its host. Once injected or drunken, the serum instantaneously allows rapid development of a muscular frame & enhanced health in its host. All the powers the host gains are superior to the likes of Nick Fury, Captain America, Red Skull or even Winter Soldier's enhanced natural strength & cybernetically-enhanced strength. The user's strength increased dramatically, enough to break down hard metal walls & the user also has an enhanced stamina. The user also gains impervious skin & highly durable physiological system. Should the subject's physiology receive any damage, the host has an accelerated healing factor that can heal the extensively damaged areas of the physiology within the space of a few hours or less. This healing & regeneration can also be responsible for their prolonged lifespan. This variant does not physical enhancements based on key personality traits.

Baron Helmut Zemo also created his own variant of the super soldier serum, which was capable of turning normal humans into feral minded abominations, with superhuman muscle mass, adrenaline, stamina, strength & endurance.


Season 1

It was mentioned by Black Widow who suggests to Iron Man to scan the Red Skull's location by tracing his blood.

Dracula wanted to suck up Captain America's super-soldier enduced blood, believing that it will make invincible and able to step out in sunlight.

Season 3

Baron Helmut Zemo, an old man in his 80's, tries to recover the lost super soldier serum, which is said to give physical abilities which are superior to Captain America's physical abilities. He "hypnotizes" Captain America into retracing his footsteps to The Zemo Castle, which houses a secret lab, where the superior super soldier serum was present. Baron Helmut Zemo used his variant of the super soldier serum to turn two of his subordinates into Hulk-sized abominations.

After Captain America stumbled upon the secret lab, Baron Helmut Zemo injected himself his father's super soldier serum. The super soldier serum's properties de-aged Baron Helmut Zemo into a man in his prime, gave him a more youthful & muscular physique as well as gave him enhanced strength, speed, stamina & a healing factor, all slightly superior to Captain America's super soldier abilities.


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